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NSC 370284
CAS No. 116409-29-1
NSC 370284( NSC370284 )
Catalog No. M10564 CAS No. 116409-29-1
NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 58 | Get Quote |
|
| 10MG | 110 | Get Quote |
|
| 25MG | 237 | Get Quote |
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| 50MG | 402 | Get Quote |
|
| 100MG | 593 | Get Quote |
|
| 500MG | 1251 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameNSC 370284
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NoteResearch use only, not for human use.
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Brief DescriptionNSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.
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DescriptionNSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo; shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent.
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In Vitro——
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In VivoAnimal Model:C57BL/6 (CD45.2) and B6.SJL (CD45.1) mice.Dosage:2.5?mg/kg.Administration:Intraperitoneal injection, once daily, for 10 days.Result:Significantly inhibited MLL-AF9 induced AML in secondary bone marrow transplantation (BMT) recipient mice.
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SynonymsNSC370284
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT
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Research Area——
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Indication——
Chemical Information
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CAS Number116409-29-1
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Formula Weight387.432
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Molecular FormulaC21H25NO6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (258.11 mM)
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SMILESCOC1=CC(=CC(=C1OC)OC)C(C2=CC3=C(C=C2O)OCO3)N4CCCC4
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Chemical Name6-(pyrrolidin-1-yl(3,4,5-trimethoxyphenyl)methyl)benzo[d][1,3]dioxol-5-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jiang X, et al. Nat Commun. 2017 Dec 13;8(1):2099.
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