NSC 370284

CAS No. 116409-29-1

NSC 370284( NSC370284 )

Catalog No. M10564 CAS No. 116409-29-1

NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 58 Get Quote
10MG 110 Get Quote
25MG 237 Get Quote
50MG 402 Get Quote
100MG 593 Get Quote
500MG 1251 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    NSC 370284
  • Note
    Research use only, not for human use.
  • Brief Description
    NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.
  • Description
    NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo; shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent.
  • In Vitro
    ——
  • In Vivo
    Animal Model:C57BL/6 (CD45.2) and B6.SJL (CD45.1) mice.Dosage:2.5?mg/kg.Administration:Intraperitoneal injection, once daily, for 10 days.Result:Significantly inhibited MLL-AF9 induced AML in secondary bone marrow transplantation (BMT) recipient mice.
  • Synonyms
    NSC370284
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    116409-29-1
  • Formula Weight
    387.432
  • Molecular Formula
    C21H25NO6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (258.11 mM)
  • SMILES
    COC1=CC(=CC(=C1OC)OC)C(C2=CC3=C(C=C2O)OCO3)N4CCCC4
  • Chemical Name
    6-(pyrrolidin-1-yl(3,4,5-trimethoxyphenyl)methyl)benzo[d][1,3]dioxol-5-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jiang X, et al. Nat Commun. 2017 Dec 13;8(1):2099.
molnova catalog
related products
  • NSC 370284

    NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.

  • Enzaplatovir

    Enzaplatovir (BTA-585) is an orally available fusion inhibitor with antiviral activity for the study of respiratory syncytial virus infections and coronavirus disease (COVID-19) infections.

  • S3I-M2001

    S3I-M2001 (Bromohydroxyacetone phosphate) is an oxazole-based peptidomimetic of the STAT3 SH2 domain-binding phosphotyrosine peptide that selectively disrupts active STAT3:STAT3 dimers.