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Home - Products - JAK/STAT Signaling - STAT - NSC 370284

NSC 370284

CAS No. 116409-29-1

NSC 370284( NSC370284 )

Catalog No. M10564 CAS No. 116409-29-1

NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NSC 370284
  • Note
    Research use only, not for human use.
  • Brief Description
    NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.
  • Description
    NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo; shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent.
  • In Vitro
    ——
  • In Vivo
    Animal Model:C57BL/6 (CD45.2) and B6.SJL (CD45.1) mice.Dosage:2.5?mg/kg.Administration:Intraperitoneal injection, once daily, for 10 days.Result:Significantly inhibited MLL-AF9 induced AML in secondary bone marrow transplantation (BMT) recipient mice.
  • Synonyms
    NSC370284
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    116409-29-1
  • Formula Weight
    387.432
  • Molecular Formula
    C21H25NO6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (258.11 mM)
  • SMILES
    COC1=CC(=CC(=C1OC)OC)C(C2=CC3=C(C=C2O)OCO3)N4CCCC4
  • Chemical Name
    6-(pyrrolidin-1-yl(3,4,5-trimethoxyphenyl)methyl)benzo[d][1,3]dioxol-5-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jiang X, et al. Nat Commun. 2017 Dec 13;8(1):2099.
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